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Wnt agonist 1

Catalog No.
B6059
agonist of Wnt signaling pathway
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$72.00
In stock
10mg
$64.00
In stock
50mg
$264.00
In stock
200mg
$485.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

Wnt agonist 1 (CAS 853220-52-7) is a small-molecule stimulator of the canonical Wnt signaling pathway. It functions by activating β-catenin-dependent transcription mediated through the TCF transcription factor, with an EC50 of approximately 0.7 μM. In Xenopus embryos treated from developmental stage 10.5 to stage 40 with Wnt agonist 1 (10 μM), notable cephalic defects—including reduced head size or absent eyes—were observed, mirroring phenotypes associated with increased Wnt signaling. Researchers use Wnt agonist 1 to investigate Wnt pathway-regulated cellular differentiation and development.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt386.83
Cas No.853220-52-7
FormulaC19H19ClN4O3
SynonymsBML-284
Solubility≥38.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Chemical Name(Z)-1-(benzo[d][1,3]dioxol-5-yl)-N-(2-imino-6-(3-methoxyphenyl)-2,3-dihydropyrimidin-4(1H)-ylidene)methanamine hydrochloride
SDFDownload SDF
Canonical SMILESCOC1=CC=CC(C(NC2=N)=C/C(N2)=N/CC3=CC4=C(OCO4)C=C3)=C1.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control