Wnt agonist 1
Catalog No.
B6059
agonist of Wnt signaling pathway
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Wnt agonist 1 (CAS 853220-52-7) is a small-molecule stimulator of the canonical Wnt signaling pathway. It functions by activating β-catenin-dependent transcription mediated through the TCF transcription factor, with an EC50 of approximately 0.7 μM. In Xenopus embryos treated from developmental stage 10.5 to stage 40 with Wnt agonist 1 (10 μM), notable cephalic defects—including reduced head size or absent eyes—were observed, mirroring phenotypes associated with increased Wnt signaling. Researchers use Wnt agonist 1 to investigate Wnt pathway-regulated cellular differentiation and development.
- 1. Wenwen Liu, Yang Zhou, et al. "Glutathione peroxidase 4-dependent glutathione high-consumption drives acquired platinum chemoresistance in lung cancer-derived brain metastasis." Clin Transl Med. 2021 Sep;11(9):e517. PMID:34586745
- 2. Yang JM, Huang HM, et al. "LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway."Toxicology. 2018 Sep 8;410:65-72. PMID:30205152
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 386.83 |
| Cas No. | 853220-52-7 |
| Formula | C19H19ClN4O3 |
| Synonyms | BML-284 |
| Solubility | ≥38.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | (Z)-1-(benzo[d][1,3]dioxol-5-yl)-N-(2-imino-6-(3-methoxyphenyl)-2,3-dihydropyrimidin-4(1H)-ylidene)methanamine hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | COC1=CC=CC(C(NC2=N)=C/C(N2)=N/CC3=CC4=C(OCO4)C=C3)=C1.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
Related Biological Data
