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Cathepsin G Inhibitor I

Catalog No.
A8174
Cathepsin G inhibitor
Grouped product items
SizePriceStock Qty
Evaluation Sample
$30.00
In stock
500ug
$70.00
Ship with 10-15 days
1mg
$120.00
Ship with 10-15 days
5mg
$420.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Cathepsin G Inhibitor I (CAS 429676-93-7) is a selective, reversible, and competitive nonpeptide inhibitor targeting the serine protease Cathepsin G (EC 3.4.21.20), an enzyme encoded by the human CTSG gene that functions in proteolytic cleavage processes. In vitro, this compound exhibits potent inhibitory activity against Cathepsin G with reported IC50 and Ki values of 53 ± 12 nM and 63 ± 14 nM, respectively, while displaying weaker inhibition against chymotrypsin (Ki = 1.5 ± 0.2 μM) and minimal inhibitory effect (<50% inhibition at 100 μM) on several other serine proteases. Cathepsin G Inhibitor I is currently utilized for preclinical research and enzymatic studies.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt620.64
Cas No.429676-93-7
FormulaC36H33N2O6P
Solubility≥10.35 mg/mL in DMSO
Chemical Name[2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid
SDFDownload SDF
Canonical SMILESCN(C1CCN(CC1)C(=O)C2=CC=CC=C2)C(=O)C3=CC4=CC=CC=C4C=C3C(=O)C(C5=CC=CC6=CC=CC=C65)P(=O)(O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Metastatic breast cancer cells and neutrophils

Reaction Conditions

2 μM cathepsin G inhibitor I for 22 h incubation

Applications

Cathepsin G inhibitor I (2 μM) reduced the formation of neutrophil extracellular traps (NETs) induced by cancer cells. In addition, cathepsin G inhibitor I (2 μM) inhibited neutrophil-stimulated invasion. Thus, inhibition of cathepsin G, a protease associated with NETs, was able to reduce the extension of NETs and block neutrophils’ ability to promote invasion.

Note

The technical data provided above is for reference only.

References:

1. Park J, Wysocki RW, Amoozgar Z, et al. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine, 2016, 8(361): 361ra138.

Biological Activity

Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G.
Targets cathepsins G          
IC50 53nM          

Quality Control

Chemical structure

Cathepsin G Inhibitor I