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Neutrophil Elastase Inhibitor

Catalog No.
C3252
neutrophil elastase inhibitor
Grouped product items
SizePriceStock Qty
5mg
$91.00
Ship with 5-10 days
10mg
$172.00
Ship with 5-10 days
25mg
$409.00
Ship with 5-10 days
50mg
$724.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

IC50: 7 nM

Neutrophil Elastase Inhibitor is a neutrophil elastase inhibitor.

Human neutrophil elastase (HNE) is a member of the chymotrypsin superfamily of serine proteases that is involved in the response to inflammatory stimuli. HNE is reported to be stored in azurophilic granules of neutrophils and is greatly aggressive and cytotoxic, as its substrates include various components of the extracellular matrix.

In vitro: Previous study found that Neutrophil Elastase Inhibitor was able to inhibit thrombin and urokinase at micromolar concentrations. In addition, Neutrophil Elastase Inhibitor appeared to be a specific HNE inhibitors in a competitive manner. Moreoer, the hydrolysis of the acyl-enzyme complex for Neutrophil Elastase Inhibitor was found to be much slower than spontaneous hydrolysis of Neutrophil Elastase Inhibitor, and HNE was observed to be still inhibited to 80% of control level at 7 h after treatment [1].

In vivo: So far, there is no animal in vivo data reported.

Clinical trial: Up to now, Neutrophil Elastase Inhibitor is still in the preclinical development stage.

References:
[1] L.  Crocetti, I. A. Schepetkin, A. Cilibrizzi, et al. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. Journal of Medicinal Chemistry 56(15), 6259-6272 (2013).

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt261.3
Cas No.1448314-31-5
FormulaC16H11N3O
Solubility≤0.5mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name1-(3-methylbenzoyl)-1H-indazole-3-carbonitrile
SDFDownload SDF
Canonical SMILESO=C(C1=CC=CC(C)=C1)N2C3=CC=CC=C3C(C#N)=N2
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Neutrophil Elastase Inhibitor