Gatifloxacin
Catalog No.
A1313
Fluoroquinolone antibiotic,inhibits bacterial TOPO II
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Gatifloxacin(CAS No. 112811-59-3) is a fluoroquinolone antibiotic that functions by inhibiting bacterial type II topoisomerases, enzymes essential for bacterial DNA replication and transcription. Specifically, it targets DNA gyrase in Gram-negative bacteria and topoisomerase IV in Gram-positive bacteria. Experimental data indicate that gatifloxacin inhibits DNA gyrase from E. coli and topoisomerase IV from S. aureus with IC50 values of approximately 0.109 μg/ml and 13.8 μg/ml, respectively. Due to this selective inhibitory action, it serves as a useful research tool in microbiological studies, investigating antimicrobial resistance mechanisms, and exploring bacterial genome replication processes.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 375.39 |
| Cas No. | 112811-59-3 |
| Formula | C19H22FN3O4 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥3.75 mg/mL in DMSO with gentle warming |
| Chemical Name | 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CC(C1)NCCN1c(c(OC)c(c1c2)N(C3CC3)C=C(C(O)=O)C1=O)c2F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
