5-Methyl-CTP
Catalog No.
B7967
5-Methyl modified cytidine triphosphate for in vitro transcription synthesis of mRNA
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5-Methyl-CTP is a modified cytidine triphosphate where the cytosine base is methylated at the fifth carbon position. This modification increases mRNA stability and translation efficiency, making it highly valuable for in vitro mRNA synthesis. When incorporated during mRNA synthesis, 5-Methyl-CTP mimics the methylation patterns of natural mRNA, thus preventing rapid degradation by cellular degradation mechanisms. Methylation not only enhances mRNA stability but also improves its translation efficiency within cells, which makes it broadly applicable in gene expression research and related mRNA drug development.
- 1. You Wu, Wenna Shao, et al. "Transfer learning enables identification of multiple types of RNA modifications using nanopore direct RNA sequencing." Nat Commun. 2024 May 14;15(1):4049. PMID: 38744925
- 2. Qiyao Chai, Shanshan Yu, et al. "A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin." Science. 2022 Oct 14;378(6616):eabq0132 PMID: 36227980
- 3. Denzil Furtado, Christina Cortez-Jugo, et al. "mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts." Mol Pharm. 2022 Nov 7;19(11):3987-3999. PMID: 36125338
- 4. Yao Li, Xiaotu Ma, et al. "Rapid Surface Display of mRNA Antigens by BacteriaDerived Outer Membrane Vesicles for a Personalized Tumor Vaccine." Adv Mater. 2022 May;34(20):e2109984. PMID: 35315546
- 5. Jingjing Zhang , Yun Li, et al. "Genome-wide CRISPR/Cas9 library screen identifes PCMT1 as a critical driver of ovarian cancer metastasis." J Exp Clin Cancer Res. PMID: 35033172
- 6. Jing Lu, Guoliang Lu, et al. "A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice." Cell Res. 2020;1-4. PMID:32801356
| Storage | Store at -20°C or below |
| M.Wt | 497.1 (free acid) |
| Cas No. | 327174-86-7 (free acid) |
| Formula | C10H18N3O14P3 (free acid) |
| SDF | Download SDF |
| Canonical SMILES | [NH2]=C(C(C)=CN1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)=NC1=O.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.91% by AX-HPLC
- COA (Certificate Of Analysis)
- HPLC
- MS (Mass Spectrometry)
- MSDS (Material Safety Data Sheet)
Chemical structure
Related Biological Data
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