5-Methoxy-UTP
Catalog No.
B8061
5-Methoxy-modified uridine triphosphate for in vitro transcription-based mRNA synthesis
Featured Products
5-Methoxy-UTP is a modified uridine triphosphate nucleotide bearing a methoxy group at the carbon-5 position. This modification significantly alters the chemical properties and biological functions of the nucleotide. During in vitro mRNA synthesis, 5-Methoxy-UTP can be incorporated into RNA molecules, generating RNAs containing 5-methoxyuridine residues. Methoxy-modified RNA plays an important role in studies focusing on RNA structure, function, and interactions with proteins. Additionally, 5-Methoxy-UTP markedly improves RNA stability and protects against intracellular degradation. Therefore, this modification is widely utilized in gene expression research, RNA drug development, and gene therapy applications.
- 1. Denzil Furtado, Christina Cortez-Jugo, et al. "mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts." Mol Pharm. PMID: 36125338
- 2. Jingjing Zhang, Yun Li, et al. "Genome-wide CRISPR/Cas9 library screen identifes PCMT1 as a critical driver of ovarian cancer metastasis." J Exp Clin Cancer Res. PMID: 35033172
- 3. Jing Lu, Guoliang Lu, et al. "A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice." Cell Res. 2020;1-4. PMID: 32801356
Quality Control & MSDS
- View current batch:
-
Purity >95% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
Related Biological Data
Store at -20°C or below