N1-Methylpseudo-UTP
Catalog No.
B8049
N1-Methyl-Pseudouridine-5'-Triphosphate, a modified nucleoside triphosphate for research on RNA translation and stability
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N1-Methylpseudo-UTP is a modified nucleoside triphosphate where the N1 position of pseudouridine is methylated. This modification significantly influences RNA structure and function, particularly in translation and stability. N1-Methylpseudo-UTP can be incorporated into RNA molecules through in vitro transcription reactions to produce RNA containing this modification. The methylation modification affects RNA secondary structure, enhances stability, and reduces degradation. Furthermore, N1-Methylpseudo-UTP is widely applied in studying RNA translation mechanisms and RNA-protein interactions.
- 1. Denzil Furtado, Christina Cortez-Jugo, et al. "mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts." Mol Pharm. PMID: 36125338
- 2. Kyusik Q Kim, Bhagyashri D Burgute, et al. "N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products." Cell Rep. PMID: 35988540
- 3. Jingjing Zhang, Yun Li, et al. "Genome-wide CRISPR/Cas9 library screen identifes PCMT1 as a critical driver of ovarian cancer metastasis." J Exp Clin Cancer Res. PMID: 35033172
Quality Control & MSDS
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Purity ≥ 90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
Store at -20°C or below