N1-Methylpseudo-UTP
Catalog No.
B8049
N1-Methyl-Pseudouridine-5'-Triphosphate, a modified nucleoside triphosphate for research on RNA translation and stability
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N1-Methylpseudo-UTP is a modified nucleoside triphosphate where the N1 position of pseudouridine is methylated. This modification significantly influences RNA structure and function, particularly in translation and stability. N1-Methylpseudo-UTP can be incorporated into RNA molecules through in vitro transcription reactions to produce RNA containing this modification. The methylation modification affects RNA secondary structure, enhances stability, and reduces degradation. Furthermore, N1-Methylpseudo-UTP is widely applied in studying RNA translation mechanisms and RNA-protein interactions.
- 1. Jeremy J R McIntyre, Connor A Horton, et al. "Different repair pathways support intact or truncated insertions by R2 retrotransposon protein." Science. 2025 Nov 13:eadz3121 PMID: 41231928
- 2. Bin Hu, William Stewart, et al. "Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA." Nature Communications volume 16, Article number: 8120 30 August(2025)
- 3. Robert V Swanda, Quanquan Ji, et al. "Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response." Mol Cell. 2023 Sep 21;83(18):3347-3359.e9 PMID: 37647899
- 4. Wandi Zhu, Lai Wei, et al. "cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice." Mol Ther Nucleic Acids. 2022 Nov 9:30:421-437 PMID: 36420215
- 5. Denzil Furtado, Christina Cortez-Jugo, et al. "mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts." Mol Pharm. 2022 Nov 7;19(11):3987-3999 PMID: 36125338
- 6. Kyusik Q Kim, Bhagyashri D Burgute, et al. "N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products." Cell Rep. 2022 Aug 30;40(9):111300 PMID: 35988540
- 7. Jingjing Zhang, Yun Li, et al. "Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis." J Exp Clin Cancer Res. 2022 Jan 15;41(1):24 PMID: 35033172
| Storage | Store at -20°C or below |
| M.Wt | 498.1 (free acid) |
| Cas No. | 1428903-59-6 (free acid) |
| Formula | C10H17N2O15P3 (free acid) |
| Chemical Name | lithium (3,4-dihydroxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C(N(C)C=C1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity ≥ 90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
