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Sotrastaurin (AEB071)

potent and selective small-molecule PKC inhibitor

Sotrastaurin (AEB071)

Catalog No. A8525
Size Price Stock Qty
5mg $242.00 In stock
25mg $952.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Sotrastaurin (AEB071)

Biological Activity

Description Sotrastaurin is a potent and selective small-molecule inhibitor of protein kinase C (PKC) with Ki value of 0.22 nM for PKCθ.
Targets PKCθ          
IC50 0.22 nM          

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Chemical Properties

Cas No. 425637-18-9 SDF Download SDF
Synonyms AEB 071;AEB-071
Chemical Name 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
Canonical SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
Formula C25H22N6O2 M.Wt 438.48
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Potent and specific inhibitor of protein kinase C (PKC) with Ki at subnanomolar to low nanomolar range for a variety of PKC isotypes while selective for >200 other kinases; an immunosuppressant that blocks early T-lymphocyte (T-cell) activation via protein kinase C inhibition.