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EGFR

EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.

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  1. ARRY-380
    A8366 ARRY-380
    Target: HER2
    Summary: Tyrosine kinase HER2 and p95-HER2 inhibitor
      ≥28.5 mg/mL
  2. AST-1306
    A8367 AST-1306
    Summary: EGFR/HER2 inhibitor
      ≥22.45 mg/mL
  3. AZD8931 (Sapitinib)
    A8375 AZD8931 (Sapitinib)
    Target: EGFR|ErbB
    Summary: ErbB inhibitor
      ≥23.7 mg/mL
  4. OSI-420 free base
    B1495 OSI-420 free base
    Summary: EGFR inhibitor
      insoluble in H2O; insoluble in EtOH; ≥51 mg/mL
  5. AST-1306 TsOH
    B1020 AST-1306 TsOH
    Summary: ErbB2 and EGFR inhibitor
      Soluble in DMSO
  6. HKI 357
    B5456 HKI 357
    Summary: irreversible inhibitor of ErbB2 (HER2) and EGFR
      Soluble in DMSO
  7. WZ3146
    A8881 WZ3146
    Summary: Mutant EGFR inhibitor, potent and irreversible
      ≥23.25 mg/mL
  8. FIIN-2
    A8696 FIIN-2
    Target: FGFR
    Summary: Irreversible inhibitor of FGFR
      ≥31.75 mg/mL
  9. EGF816
    B5889 EGF816
     2 Citation
    Target: EGFR
    Summary: Novel covalent inhibitor of mutant-selective EGFR
      Soluble in DMSO
  10. CL-387785 (EKI-785)
    B5899 CL-387785 (EKI-785)
    Summary: Irreversible inhibiter of EGFR
      insoluble in EtOH; insoluble in H2O; ≥16.85 mg/mL

Items 21-30 of 69

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