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A-317491

Catalog No.
A3134
P2X3 and P2X2/3 receptor antagonist
Grouped product items
SizePriceStock Qty
5mg
$100.00
In stock
10mg
$148.00
In stock
25mg
$316.00
In stock
50mg
$454.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

A-317491 (CAS: 475205-49-3) is a selective, high-affinity antagonist targeting the P2X3 and heteromeric P2X2/3 receptors, ligand-gated ion channels responsive to ATP, primarily located on sensory neurons involved in pain signaling. It demonstrates potent inhibition, with reported Ki values of 9 nM (P2X2/3) and 22 nM (P2X3). In rat dorsal root ganglion neurons, A-317491 suppresses receptor-mediated currents (IC50 = 15 nM) in a dose-dependent manner. In animal models, intrathecal or peripheral administration attenuates hyperalgesia associated with inflammation and neuropathic pain, underscoring its utility in pain research.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt565.57
Cas No.475205-49-3
FormulaC33H27NO8
SynonymsA 317491;A317491
Solubility≥56.6 mg/mL in DMSO; insoluble in H2O; ≥40.73 mg/mL in EtOH with gentle warming
Chemical Name5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid
SDFDownload SDF
Canonical SMILESC1CC(C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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