A-317491
Catalog No.
A3134
P2X3 and P2X2/3 receptor antagonist
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A-317491 (CAS: 475205-49-3) is a selective, high-affinity antagonist targeting the P2X3 and heteromeric P2X2/3 receptors, ligand-gated ion channels responsive to ATP, primarily located on sensory neurons involved in pain signaling. It demonstrates potent inhibition, with reported Ki values of 9 nM (P2X2/3) and 22 nM (P2X3). In rat dorsal root ganglion neurons, A-317491 suppresses receptor-mediated currents (IC50 = 15 nM) in a dose-dependent manner. In animal models, intrathecal or peripheral administration attenuates hyperalgesia associated with inflammation and neuropathic pain, underscoring its utility in pain research.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 565.57 |
| Cas No. | 475205-49-3 |
| Formula | C33H27NO8 |
| Synonyms | A 317491;A317491 |
| Solubility | ≥56.6 mg/mL in DMSO; insoluble in H2O; ≥40.73 mg/mL in EtOH with gentle warming |
| Chemical Name | 5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | C1CC(C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
