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Home >> Signaling Pathways >> Proteases >> HIV Integrase

HIV Integrase

Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.

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Biochemicals

  1. Cat.No. Product Name Information
  2. A4069 BMS-707035 HIV-I integrase inhibitor,potent and specific
  3. A4072 MK-2048 Integrase inhibitor for HIV-1,second generation
  4. C4787 Equisetin HIV-1 integrase inhibitor
  5. B5856 GSK1349572 sodiuM salt Next-generation HIV integrase (IN) inhibitor
  6. B4851 (±)-BI-D integrase inhibitor
  7. B4845 BI 224436 novel HIV-1 non-catalytic-site integrase inhibitor
  8. A8566 GSK744 (S/GSK1265744) HIV integrase inhibitor, oral active and long-acting
  9. A4070 Elvitegravir (GS-9137) HIV-1 integrase inhibitor,potent
  10. A4071 Fluorouracil (Adrucil) Antitumor agent;inhibitor of thymidylate synthase
  11. A4073 Raltegravir (MK-0518) HIV-1 integrase inhibitor
  12. A4074 S/GSK1349572 HIV integrase inhibitor, novel and potent
  13. A3461 HIV-1 integrase inhibitor Uesful for anti-HIV
  14. A3653 Nelfinavir Mesylate HIV protease inhibitor,antiretroviral drug for HIV treatment
  15. B1122 Nelfinavir HIV-1 protease inhibitor