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K-252c

cell-permeable PKC inhibitor

K-252c

Catalog No. A8344
Size Price Stock Qty
1mg $104.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

K-252c

Biological Activity

Description K-252c is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 value of 2.45 μM.
Targets PKC PKA        
IC50 2.45 μM 25.7 μM        

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Chemical Properties

Cas No. 85753-43-1 SDF Download SDF
Synonyms Staurosporinone
Chemical Name 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Canonical SMILES O=C1C2=C(C3=CC=CC=C3N4)C4=C(NC5=CC=CC=C65)C6=C2CN1
Formula C20H13N3O M.Wt 311.34
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).