Related Biochemicals
Related Antibodies
K-252c |
cell-permeable PKC inhibitor |
Sample solution is provided at 25 µL, 10mM.
Quality Control & MSDS
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Chemical structure
| Description | K-252c is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 value of 2.45 μM. | |||||
| Targets | PKC | PKA | ||||
| IC50 | 2.45 μM | 25.7 μM | ||||
K-252c Dilution Calculator
K-252c Molarity Calculator
| Cas No. | 85753-43-1 | SDF | Download SDF |
| Synonyms | Staurosporinone | ||
| Chemical Name | 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one | ||
| Canonical SMILES | O=C1C2=C(C3=CC=CC=C3N4)C4=C(NC5=CC=CC=C65)C6=C2CN1 | ||
| Formula | C20H13N3O | M.Wt | 311.34 |
| Solubility | Soluble in DMSO > 10 mM | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).
