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Atazanavir sulfate (BMS-232632-05)

In stock
Catalog No.
A4040
Protease inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$180.00
In stock
5mg
$70.00
In stock
10mg
$100.00
In stock
25mg
$160.00
In stock
50mg
$250.00
In stock

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Background

Atazanavir sulfate (BMS-232632-05) is the sulfate salt form of atazanavir, a potent protease inhibitor (IP) for the treatment of human immunodeficiency virus 1 (HIV-1) infection, which prevents the formation of mature HIV virions through the selective inhibition of the virus-specific processing of viral gag and gag-pol polyproteins in infected cells. Although it shows strong anti-HIV-1 activity with MIC50 ranging from 2 to 5 nM, atazanavir has lower antiviral activity against HIV-2 isolates. Atazanavir, which is metabolized by the hepatic cytochrome P450 (CYP) system resulting in two main inactive metabolites, is also an inhibitor of CYP3A4 isoenzyme and P-glycoprotein ATP-dependent efflux pump.

Reference

Robin Wood. Atazanavir: its role in HIV treatment. Expert Rev Snti Infect Ther 2008; 6(6): 785-796

Chemical Properties

StorageStore at -20°C
M.Wt802.9
Cas No.229975-97-7
FormulaC38H52N6O7.H2SO4
SynonymsAtazanavir Bisulfate SaltSee A790051,BMS232632-05
Solubility≥28.7 mg/mL in DMSO with gentle warming, ≥4.05 mg/mL in EtOH with ultrasonic and warming, <2.43 mg/mL in H2O
Chemical Namemethyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid
SDFDownload SDF
Canonical SMILESCC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Chemical structure

Atazanavir sulfate (BMS-232632-05)

Related Biological Data

Atazanavir sulfate (BMS-232632-05)

Related Biological Data

Atazanavir sulfate (BMS-232632-05)