Atazanavir
Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir.
Reference
Fuster D, Clotet B. Review of atazanavir: a novel HIV protease inhibitor. Expert Opin Pharmacother. 2005 Aug;6(9):1565-72.
Croom KF, Dhillon S, Keam SJ. Atazanavir: a review of its use in the management of HIV-1 infection. Drugs. 2009 May 29;69(8):1107-40. doi: 10.2165/00003495-200969080-00009.
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| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 704.9 |
| Cas No. | 198904-31-3 |
| Formula | C38H52N6O7 |
| Solubility | ≥28.6 mg/mL in DMSO; insoluble in H2O; ≥9.9 mg/mL in EtOH with ultrasonic |
| Chemical Name | methyl ((5S,8S,9S,14S)-8-benzyl-5-(tert-butyl)-9-hydroxy-15,15-dimethyl-3,6,13-trioxo-11-(4-(pyridin-2-yl)benzyl)-2-oxa-4,7,11,12-tetraazahexadecan-14-yl)carbamate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)([C@H](NC(OC)=O)C(N[C@H]([C@@H](O)CN(NC([C@@H](NC(OC)=O)C(C)(C)C)=O)CC1=CC=C(C2=CC=CC=N2)C=C1)CC3=CC=CC=C3)=O)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | Atazanavir is an inhibitor of HIV protease with Ki of 2.66 nM. | |||||
| Targets | HIV | |||||
| IC50 | 2.6~5.3 nM | |||||
Quality Control & MSDS
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Chemical structure
