Toggle Nav
  • Menu
  • Setting

type II collagen fragment

Catalog No.
Specific for cartilaginous tissues
Grouped product items
SizePriceStock Qty
In stock
In stock
In stock
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors


Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), may be a critical event in the pathology of many arthritides, due in part to the very slow rate of collagen turnover within the cartilage2.   

Type II collagen and aggrecan (a large, aggregating proteoglycan) are the two major components of the extracellular matrix of cartilage. The collagen, which is present in a fibrillar form, provides tensile strength whereas the aggrecan is responsible for compressive stiffness of cartilage3-5. Early damage to type II collagen is predominantly pericellular/ territorial suggests that in the majority of cases collagen damage was mediated by the chondrocyte.



Figure1. Structure of Type II collagen


Figure2. Formula of Type II collagen fragmen


1.Eyre, D.R. 1987. Collagen cross-linking amino acids. Methods Enzymol. 144:115–139.

2.McAnulty, R.J., and G.J. Laurent. 1990. In vivo measurement of collagen metabolism in cartilage and bone. In Methods in Cartilage Research. A. Maroudas and K. Kuettner, editors. Academic Press Inc., San Diego, CA. 140–142.

3.Kempson, G. 1980. The mechanical properties ofarticular cartilage. In The Joints and Synovial Fluid. Volume 2. L. Sokoloff, editor. Academic Press Inc.,New York. 238-239.

4.Schmidt, M. B., V. C. Mow, L. E. Chun, and D. R. Eyre. 1990. Effects of proteoglycan extraction on the tensile behaviour ofarticular cartilage. J. Orthop. Res. 8:353-363.

5.Poole, A. R. 1993. Cartilage in health and disease. In Arthritis and Allied Conditions: A Textbook of Rheumatology. D. J. McCarty and W. J. Koopman, editors. Lea & Febiger, Philadelphia. 279-333.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Solubility≥147.1mg/mL in DMSO
SDFDownload SDF
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

type II collagen fragment