Beta-Sheet Breaker Peptide iAβ5
Beta-Sheet Breaker Peptide iAβ5 (CAS: 182912-74-9) is a synthetic pentapeptide (sequence: H-Leu-Pro-Phe-Phe-Asp-OH; C33H43N5O8) designed to disrupt β-sheet structures within amyloid-β (Aβ) aggregates. By interfering with amyloid fibrillogenesis, iAβ5 inhibits the formation and deposition of Aβ fibrils in vivo. Preclinical studies in amyloidosis rat models demonstrate that administration of iAβ5 significantly reduces cerebral Aβ accumulation and prevents amyloid fibril formation. These findings support its utility as a molecular tool for investigating the pathogenic mechanisms of amyloid deposition and evaluating therapeutic strategies in Alzheimer's disease research.
References:
1. C. Soto, E.M. Sigurdsson, L. Morelli, R.A. Kumar, E.M. Castano, and B. Frangione, Nat. Med., 4, 822 (1998) (Original; Pharmacol.)
2. MA Chacon, MI Barria, C Soto and NC Inestrosa. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 637.73 |
| Cas No. | 182912-74-9 |
| Formula | C33H43N5O8 |
| Synonyms | H2N-Leu-Pro-Phe-Phe-Asp-OH |
| Solubility | ≥63.7 mg/mL in DMSO; ≥16.33 mg/mL in EtOH; ≥6.9 mg/mL in H2O with ultrasonic |
| SDF | Download SDF |
| Canonical SMILES | N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
