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Angiotensin Receptor

The angiotensin receptors are seven-membrane G-protein-coupled receptors. They mediate the cardiovascular and other effects of angiotensin II which is a bioactive peptide of the renin–angiotensin system.

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  2. B1073 Tranilast Sodium Tranilast has been approved in Japan and South Korea, since 1982, for the treatment of bronchial asthma, with indications for keloids and hypertrophic scar added in 1993.
  3. B1214 Perindopril Perindopril is an inhibitor of angiotensin-I converting enzyme (ACE) .
  4. B1072 Losartan Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
  5. B1071 Azilsartan medoxomil monopotassium Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
  6. B1746 Eprosartan Mesylate Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.
  7. B1213 AVE 0991 sodium salt AVE 0991 is a nonpeptide Ang-(1-7) receptor Mas agonist, represents an important step for exploration of the effects of Ang-(1-7) and testing of its potential as a cardiovascular drug.
  8. B1007 AVE 0991 AVE 0991 is an agonist of angiotensin-(1-7) receptor .
  9. B1070 AHU-377(Sacubitril) AHU-377 is an inhibitor of neprilysin with IC50 value of 5nM .
  10. B2210 Azilsartan Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist with IC50 of 2.6 nM.
  11. B2218 Azilsartan Medoxomil Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.

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