| β-PompilidotoxinSlows Na+ channel inactivation |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
β-Pompilidotoxin Dilution Calculator
β-Pompilidotoxin Molarity Calculator
| Cas No. | 216064-36-7 | SDF | Download SDF |
| Synonyms | Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu | ||
| Chemical Name | β-Pompilidotoxin | ||
| Canonical SMILES | CCC(C)C(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)N)NC(=O)C(CCCN=C(N)N)N | ||
| Formula | C71H124N22O17 | M.Wt | 1557.9 |
| Solubility | Soluble to 1 mg/ml in sterile water | Storage | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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β-Pompilidotoxin, (C71H124N22O17), a peptide with the sequence H2N-Arg
-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-amide, MW= 1557.88. Pompilidotoxin is a toxin from the venom of spider wasps that slows the inactivation of Na+channels. α-Pompilidotoxin (α-PMTX) can be extracted from the venom of a solitary wasp, Anopolis samariensis. β-Pompilidotoxin (β-PMTX) originates from the venom of another wasp, Batozonellus maculifrons(1). Homology α-PMTX has no structural homology with other toxins. It lacks disulfide bonds which are known to be present in other toxins acting on sodium channels, such as sea anemone toxins or scorpion toxins(2). Both α- and β-PMTX slow the inactivation of neuronal sodium channels (but not heart sodium channels), possibly by binding to the neurotoxin receptor site 3 on the extracellular surface of the sodium channel(3). β-PMTX has higher potency than α-PMTX. By slowing down the inactivation of sodium channels, PMTXs can potentiate synaptic transmission in the lobster neuromuscular endplate.
Figure1 Formula of β-Pompilidotoxin
Ref:
1. Konno K, Hisada M, Itagaki Y, Naoki H, Kawai N, Miwa A, Yasuhara T, Takayama H (1998). "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms". Biochem Biophys Res Commun. 250 (3): 612–6.
2. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HP, Kawai N (2000). "A new class of neurotoxin from wasp venom slows inactivation of sodium current". Eur J Neurosci. 12 (6): 1961–70.
3. Kawai N, Konno K (2004). "Molecular determinants of two neurotoxins that regulate sodium current inactivation in rat hippocampal neurons". Neurosci Lett. 361 (1-3): 44–6.
