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β-Pompilidotoxin

Catalog No.
A1132
Slows Na+ channel inactivation
Grouped product items
SizePriceStock Qty
1mg
$40.00
In stock
5mg
$120.00
In stock
10mg
$200.00
In stock
25mg
$280.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

β-Pompilidotoxin, (C71H124N22O17), a peptide with the sequence H2N-Arg

-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-amide, MW= 1557.88. Pompilidotoxin is a toxin from the venom of spider wasps that slows the inactivation of Na+channels. α-Pompilidotoxin (α-PMTX) can be extracted from the venom of a solitary wasp, Anopolis samariensis. β-Pompilidotoxin (β-PMTX) originates from the venom of another wasp, Batozonellus maculifrons(1). Homology α-PMTX has no structural homology with other toxins. It lacks disulfide bonds which are known to be present in other toxins acting on sodium channels, such as sea anemone toxins or scorpion toxins(2). Both α- and β-PMTX slow the inactivation of neuronal sodium channels (but not heart sodium channels), possibly by binding to the neurotoxin receptor site 3 on the extracellular surface of the sodium channel(3). β-PMTX has higher potency than α-PMTX. By slowing down the inactivation of sodium channels, PMTXs can potentiate synaptic transmission in the lobster neuromuscular endplate.

 A1132_1

Figure1  Formula of β-Pompilidotoxin

Ref:

1. Konno K, Hisada M, Itagaki Y, Naoki H, Kawai N, Miwa A, Yasuhara T, Takayama H (1998). "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms". Biochem Biophys Res Commun. 250 (3): 612–6.

2. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HP, Kawai N (2000). "A new class of neurotoxin from wasp venom slows inactivation of sodium current". Eur J Neurosci. 12 (6): 1961–70.

3. Kawai N, Konno K (2004). "Molecular determinants of two neurotoxins that regulate sodium current inactivation in rat hippocampal neurons". Neurosci Lett. 361 (1-3): 44–6.

 

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at -20°C
M.Wt1557.9
Cas No.216064-36-7
FormulaC71H124N22O17
SynonymsArg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu
Solubility≥155.8mg/mL in DMSO
Chemical Nameβ-Pompilidotoxin
SDFDownload SDF
Canonical SMILESCCC(C)C(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)N)NC(=O)C(CCCN=C(N)N)N
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

β-Pompilidotoxin