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Myelopeptide-2 (MP-2)

Catalog No.
A1010
Peptide used for restoring human T lymphocytes
Grouped product items
SizePriceStock Qty
1mg
$40.00
In stock
5mg
$120.00
In stock
10mg
$200.00
In stock
25mg
$280.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Myelopeptide-2 (MP-2) (C41H57N7O8), with the sequence Leu-Val-Val-Tyr-Pro-Trp, is originally isolated from the supernatant of porcine bone marrow cell culture, and is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from HL-60 leukemia cells or measles virus. The MP-2 recovery effect is connected with its influence on the CD3 and CD4 antigen expression on T lymphocytes. Research results also suggest that the MP-2 involvement in regulatory processes is directed to the maintenance of immune homeostasis. This peptide is perspective to be applied in antitumor and antivirus therapy.

A1010_1 

Ref:

1. Mikhailova AA, Belevskaya RG, Kalyuzhnaya M, Fonina LA, Liashenko VA, Petrov RV. Myelopeptide-2 recovers interleukin-2 synthesis and interleukin-2 receptor expression in human T lymphocytes depressed by tumor products or measles virus.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt775.93
FormulaC41H57N7O8
SynonymsH2N-Leu-Val-Val-Tyr-Pro-Trp-OH
Solubility≥77.5 mg/mL in DMSO; insoluble in H2O; ≥44.8 mg/mL in EtOH
SDFDownload SDF
Canonical SMILESN[[email protected]@H](CC(C)C)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](CC1=CC=C(O)C=C1)C(N2[[email protected]@H](CCC2)C(N[[email protected]@H](CC3=CC(C=CC=C4)=C4N3)C(O)=O)=O)=O)=O)=O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Myelopeptide-2 (MP-2)