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Necrostatin-1

specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis

Necrostatin-1

Catalog No. A4213
Size Price Stock Qty
10mg $60.00 In stock
100mg $170.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Necrostatin-1

Related Biological Data

Necrostatin-1

Biological Activity

Description Necrostatin-1 is a specific inhibitor of RIP1 and inhibits TNF-α-induced necroptosis with an EC50 value of 490 nM.
Targets RIP1          
IC50 490 nM (EC50)          

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Chemical Properties

Cas No. 4311-88-0 SDF Download SDF
Synonyms MTH-DL-Tryptophan,Nec-1
Chemical Name 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
Canonical SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
Formula C13H13N3OS M.Wt 259.33
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.