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Lenalidomide hydrochloride

Catalog No.
A3547
TNF-α secretion inhibitor
Grouped product items
SizePriceStock Qty
50mg
$90.00
In stock
100mg
$120.00
In stock
250mg
$150.00
In stock
500mg
$180.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

IC50 Value: 13 nM [1] Lenalidomideis a derivative of thalidomide introduced in 2004. Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM. in vitro: Lenalidomide strongly induces IL-2 and sIL-2R production. Lenalidomide-induced tyrosine phosphorylation of CD28 on T cells is followed by a down-stream activation of NF-κB [2]. Lenalidomide and pomalidomide inhibits autoubiquitination of CRBN in HEK293 T cells expressing thalidomide-binding competent wild-type CRBN, but not thalidomide-binding defective CRBN (YW/AA). Overexpression of CRBN wild-type protein, but not CRBN (YW/AA) mutant protein, in KMS12 myeloma cells, amplifies pomalidomide-mediated reductions in c-myc and IRF4 expression and increases in p21(WAF-1) expression. Long-term selection for Lenalidomide resistance in H929 myeloma cell lines is accompanied by a reduction in CRBN, while in DF15R myeloma cells resistant to both pomalidomide and Lenalidomide, CRBN protein is undetectable [3]. in vivo: Pharmacokinetic studies evaluated doses of 0.5, 1.5, 5, and 10 mg/kg IV and 0.5 and 10 mg/kg doses for IP and oral routes. Liquid chromatography-tandem mass spectrometry was used to quantify lenalidomide in plasma, brain, lung, liver, heart, kidney, spleen, and muscle [4]. Treatment with either thalidomide or lenalidomide attenuated weight loss, enhanced motor performance, decreased motor neuron cell death, and significantly increased the life span in G93A transgenic mice [5]. Toxicity: International Staging System III received a combination therapy of lenalidomide (15 mg, Day 1 - 21) with dexamethasone (40 mg, Day 1, 8, 15, 22). After 4 days on chemotherapy, he experienced worsened dyspnea and was urgently hospitalized because of acute respiratory failure [6]. Clinical trial: Lenalidomide As Immune Adjuvant In Patient's With Chronic Lymphocytic Leukemia (CLL). Phase 2

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt295.72
Cas No.1243329-97-6
FormulaC13H14ClN3O3
SynonymsRevlimid hydrochloride;CC-5013 hydrochloride;CC5013 hydrochloride;CC 5013 hydrochloride
Solubilityinsoluble in H2O; ≥1.83 mg/mL in EtOH; ≥72.2 mg/mL in DMSO
Chemical Name3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
SDFDownload SDF
Canonical SMILESO=C1N(C2C(NC(CC2)=O)=O)CC3=C(N)C=CC=C31.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Lenalidomide hydrochloride

Related Biological Data

Lenalidomide hydrochloride

Related Biological Data

Lenalidomide hydrochloride

Related Biological Data

Lenalidomide hydrochloride