Necrostatin 2
Necrostatin 2 (Nec-2) is a novel and potent necroptosis inhibitor with EC50 of 50 nM. It is an analog of necrostatin 1 (nec-1).
Necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.
Nec-2 is efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. There is limited record for Nec-2, but some reports are related with other necrostatins. Nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP1 in vitro.
Reference:
[1]. Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40.
- 1. Mengyun Yang, Ze Yu, et al. "Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection." Sci Adv. 2025 Aug 15;11(33):eadx6587. PMID: 40815641
- 2. Sieber J, Wieder N, et al. "GDC-0879, a BRAF(V600E) Inhibitor, Protects Kidney Podocytes from Death." Cell Chem Biol. 2017 Dec 6. PMID: 29249695
- 3. Ma Y, Walsh MJ, et al. "CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors." Cell Host Microbe. 2017 May 10;21(5):580-591.e7. PMID: 28494239
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 277.71 |
| Cas No. | 852391-19-6 |
| Formula | C13H12ClN3O2 |
| Synonyms | MTH-DL-Tryptophan, Necroptotic Inhibitor |
| Solubility | Soluble in DMSO |
| Chemical Name | (5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | CN(C([C@@H](Cc(c1ccc2)c[nH]c1c2Cl)N1)=O)C1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | Necrostatin-2 (Nec-2) is a small molecule inhibitor of RIPK2 kinase activity | |||||
| Targets | RIPK2 | |||||
| IC50 | ||||||
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
