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Go 6976

Go 6976

Catalog No. A8341
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1mg $137.00 Please Inquiry

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Go 6976

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Chemical Properties

Cas No. 136194-77-9 SDF Download SDF
Synonyms Go6976;Go-6976
Chemical Name 3-(13-methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile
Canonical SMILES O=C1NCC2=C3C(N(CCC#N)C4=CC=CC=C34)=C5N(C)C6=CC=CC=C6C5=C21
Formula C24H18N4O M.Wt 378.43
Solubility Soluble in DMSO Storage Desiccate at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.