Related Biochemicals Related Antibodies
|Potent and selective protein kinase C inhibitor, specifically inhibits α and β1 isoforms|
Sample solution is provided at 25 µL, 10mM.
|Description||GF109203X is a potent inhibitor of PKC with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively.|
|IC50||20 nM||17 nM||16 nM||20 nM|
|Cas No.||133052-90-1||SDF||Download SDF|
|Synonyms||Gö 6850;Bisindolylmaleimide I|
|Solubility||Soluble in DMSO > 10 mM||Storage||Store at RT|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Anti-inflammatory in vivo.