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GF 109203X

Potent and selective protein kinase C inhibitor, specifically inhibits α and β1 isoforms

GF 109203X

Catalog No. A8342
Size Price Stock Qty
Evaluation Sample $28.00  All Inclusive In stock
1mg $60.00 In stock
10mg $123.00 In stock

All inclusive: Shipping and all other fees included

Tel: +1-832-696-8203

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

GF 109203X

Related Biological Data

GF 109203X

Related Biological Data

GF 109203X

Biological Activity

Description GF109203X is a potent inhibitor of PKC with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively.
Targets PKCα PKCβI PKCβII PKCγ    
IC50 20 nM 17 nM 16 nM 20 nM    

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Chemical Properties

Cas No. 133052-90-1 SDF Download SDF
Synonyms Gö 6850;Bisindolylmaleimide I
Chemical Name 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
Canonical SMILES CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
Formula C25H24N4O2 M.Wt 412.49
Solubility Soluble in DMSO Storage Store at RT
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Anti-inflammatory in vivo.