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Dynamin inhibitory peptide

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Peptide inhibitor of GTPase dynamin
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Dynamin Inhibitory Peptide is a peptide (Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro) inhibitor of the GTPase dynamin.

Dynamin is a 100-kDa large GTPase that functions to tabulate membranes and liberate nascent vesicles from the Golgi apparatus and plasma membrane. Dynamin also plays a role in many processes including division of organelles,cytokinesis and microbial pathogen resistance.

Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.


Figure1  Formula of Dynamin Inhibitory Peptide


1. McNiven, M. A., Cao, H., Pitts, K. R. & Yoon, Y. (2000) Trends Biochem. Sci. 25, 115–120.

2. Hinshaw, J. E. (2000) Annu. Rev. Cell Dev. Biol 16, 483–519.

3. Thoms S, Erdmann R (Oct 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.". FEBS J 272 (20): 5169–81.

4. Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419-25.

5. Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972-7. 

6. Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302-7. 

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at -20°C
Cas No.251634-21-6
Solubility≥112.1mg/mL in DMSO
Chemical NameDynamin inhibitory peptide
SDFDownload SDF
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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Chemical structure

Dynamin inhibitory peptide