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Cy3 alkyne (non-sulfonated)

Catalog No.
used for Click chemistry to label any molecule bearing azide group.
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Cy3 alkyne is a water-insoluble dye ready for the use in Click Chemistry reaction. With this bright and photostable reagent, molecules bearing azide group can be attached by it. The reagent can be efficiently attached to water-soluble molecules such as proteins when used with organic co-solvent (DMSO or DMF). For biomolecule labeling, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines.

In dendritic cells, the research confirming that the conjugates of Cy3-alkyne and Cy5-BSA-pDMDOMA particles are internalized by the cells rather than sticking to the cell surface. Additionally, confocal microscopy imaging shows a strong co-localization of the Cy3 and Cy5 channel [1].

[1] Vanparijs, N. ; De Coen, R.; Laplace, D.R.; Louage, B.; Maji, S.; Lybaert, L.; Hoogenboom, R.; De Geest, B. Transiently responsive protein-polymer conjugates via a grafting-from RAFT approach: for intracellular co-delivery of proteins and immune-modulators.Chemical Communications, 2015, 51, 13972–13975.

Chemical Properties

Physical AppearanceA solid
StorageStorage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Solubilitysoluble in organic solvents (DMF, DMSO, dichloromethane), insoluble in water
Chemical Name6-[(2E)-3,3-dimethyl-2-[(E)-3-(1,3,3-trimethylindol-1-ium-2-yl)prop-2-enylidene]indol-1-yl]-N-prop-2-ynylhexanamide
SDFDownload SDF
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.

Spectral properties

Excitation max (nm) 555 Emission max (nm) 570
Extinction Coefficient (M-1cm-1) 150000 Quantum Yield 0.31
CF260 0.04 CF280 0.09

Quality Control

Chemical structure

Cy3 alkyne

Related Biological Data

Cy3 alkyne