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Ac-Endothelin-1 (16-21), human

Catalog No.
ETA/ETB agonist,vasoconstrictor
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ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues, including the heart, the kidney, and the central nervous system.

At the cellular level, the effects of ET-1 appear to be mediated by two specific receptor subtypes termed ETA and ETB, both of which are functionally coupled to phospholipase C (PLC).

The  C-terminal  fragment ,  which  is  a  highly  conserved  sequence  in the  peptides  of  the  ET  family,  has  been shown  to  discriminate  between  the  two  ET  receptor  subtypes  termed  ETA  and  ETB  since  it  activates  only  the  latter  ones.


1. Rubanyi, G. M., and M. A. Polokoff. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46: 325–415, 1994

2. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375–411.

3. PM Vanhoutte Endothelin-1. A matter of life and breath, Nature, 368 (1994), pp. 693–694


Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Solubility≥83.8mg/mL in DMSO with gentle warming
SDFDownload SDF
Canonical SMILESO=C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CC(O)=O)C(N[[email protected]@H]([[email protected]](C)CC)C(N[[email protected]@H]([[email protected]](C)CC)C(N[[email protected]@H](CC1=CC(C=CC=C2)=C2N1)C(O)=O)=O)=O)=O)=O)[[email protected]](CC3=CNC=N3)NC(C)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Ac-Endothelin-1 (16-21), human