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Ac-Endothelin-1 (16-21), human
ETA/ETB agonist,vasoconstrictor

Ac-Endothelin-1 (16-21), human

Catalog No. A1016
Size Price Stock Qty
1mg $30.00 In stock
5mg $90.00 In stock
10mg $150.00 In stock
25mg $210.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Ac-Endothelin-1 (16-21), human

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Chemical Properties

Cas No. SDF Download SDF
Synonyms Ac-His-Leu-Asp-Ile-Ile-Trp-OH
Canonical SMILES O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](C)CC)C(N[C@@H]([C@H](C)CC)C(N[C@@H](CC1=CC(C=CC=C2)=C2N1)C(O)=O)=O)=O)=O)=O)[C@H](CC3=CNC=N3)NC(C)=O
Formula C41H59N9O10 M.Wt 837.96
Solubility Storage Store at -20°C
General tips N/A
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Background

ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues, including the heart, the kidney, and the central nervous system.

At the cellular level, the effects of ET-1 appear to be mediated by two specific receptor subtypes termed ETA and ETB, both of which are functionally coupled to phospholipase C (PLC).

The  C-terminal  fragment ,  which  is  a  highly  conserved  sequence  in the  peptides  of  the  ET  family,  has  been shown  to  discriminate  between  the  two  ET  receptor  subtypes  termed  ETA  and  ETB  since  it  activates  only  the  latter  ones.

Ref:

1. Rubanyi, G. M., and M. A. Polokoff. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46: 325–415, 1994

2. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375–411.

3. PM Vanhoutte Endothelin-1. A matter of life and breath, Nature, 368 (1994), pp. 693–694

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