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Rac GTPase fragment

Catalog No.
A1086
Fragment of small signaling G proteins
Grouped product items
SizePriceStock Qty
1mg
$50.00
In stock
5mg
$150.00
In stock
10mg
$250.00
In stock
25mg
$350.00
In stock

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Email: [email protected]

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Background

Rac GTPase fragment, (C46H74N12O14), a peptide with the sequence H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH, MW= 1019.15. Rac is a subfamily of the Rho family of GTPases, small signaling G proteins (more specifically a GTPase). Rac1 is thought to play a significant role in the development of various cancers, including melanoma (1) and non-small cell lung cancer(2). Rac1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases Rac1 is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the actin network), and of epithelial differentiation (3).

A1086_1 

Figurestructure of Rac GTPase 1

A1086_2  

FigureThe Rac GTPase pathway

 

Ref:

1. Hodis, E; Watson, IR; Kryukov, GV; Arold, ST; Imielinski, M; Theurillat, JP; Nickerson, E; Auclair, D; Li, L; Place, C; Dicara, D; Ramos, AH; Lawrence, MS; Cibulskis, K; Sivachenko, A; Voet, D; Saksena, G; Stransky, N; Onofrio, RC; Winckler, W; Ardlie, K; Wagle, N; Wargo, J; Chong, K; Morton, DL; Stemke-Hale, K; Chen, G; Noble, M; Meyerson, M; Ladbury, JE; Davies, MA; Gershenwald, JE; Wagner, SN; Hoon, DS; Schadendorf, D; Lander, ES; Gabriel, SB; Getz, G; Garraway, LA; Chin, L (2012 Jul 18). "A landscape of driver mutations in melanoma.". Cell.

2. Stallings-Mann, M. L.; Waldmann, J.; Zhang, Y.; Miller, E.; Gauthier, M. L.; Visscher, D. W.; Downey, G. P.; Radisky, E. S. et al. (2012). "Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression". Science Translational Medicine 4 (142): 142ra95–142ra95.

3. Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1019.15
FormulaC46H74N12O14
SynonymsH2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH
Solubility≥101.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
SDFDownload SDF
Canonical SMILESNC(C(C)C)C(NC(CC1=CC=CC=C1)C(NC(CC(O)=O)C(NC(CCC(O)=O)C(NC(C)C(NC(C(NC(CCCNC(N)=N)C(NC(C)C(NC(C(C)C)C(O)=O)=O)=O)=O)C(C)CC)=O)=O)=O)=O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Rac GTPase fragment