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NB-598 hydrochloride

Catalog No.
A3646
SE inhibitor
Grouped product items
SizePriceStock Qty
5mg
$246.00
In stock
10mg
$339.00
In stock
50mg
$986.00
In stock
200mg
$2,262.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

NB-598 hydrochloride (CAS 136719-25-0) is a benzylamine derivative that selectively inhibits squalene epoxidase (SQLE), a crucial enzyme in cholesterol biosynthesis. Acting as a competitive inhibitor, NB-598 interferes with SQLE-catalyzed conversion of squalene, displaying IC50 values of 4.4 nM and 0.75 nM in cell-free and HepG2 microsomal assays, respectively. In HepG2 cells, NB-598 inhibits cholesterol synthesis (IC50 = 3.4 nM) without affecting triglycerides, phospholipids, or fatty acids. In vivo, it reduces serum cholesterol in rodents and dogs by upregulating LDL receptor activity. Thus, NB-598 serves as a valuable compound in hypercholesterolemia and atherosclerosis research.

Chemical Properties

StorageStore at -20°C
M.Wt486.13
Cas No.136719-25-0
FormulaC27H32ClNOS2
SynonymsNB 598 hydrochloride;NB598 hydrochloride
Solubility≥54 mg/mL in DMSO with gentle warming, ≥49.3 mg/mL in EtOH with gentle warming,insoluble in H2O
Chemical Name(E)-N-ethyl-6,6-dimethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]hept-2-en-4-yn-1-amine;hydrochloride
SDFDownload SDF
Canonical SMILESCCN(CC=CC#CC(C)(C)C)CC1=CC(=CC=C1)OCC2=CC(=CS2)C3=CSC=C3.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

NB-598 hydrochloride