NB-598 hydrochloride
Catalog No.
A3646
SE inhibitor
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NB-598 hydrochloride (CAS 136719-25-0) is a benzylamine derivative that selectively inhibits squalene epoxidase (SQLE), a crucial enzyme in cholesterol biosynthesis. Acting as a competitive inhibitor, NB-598 interferes with SQLE-catalyzed conversion of squalene, displaying IC50 values of 4.4 nM and 0.75 nM in cell-free and HepG2 microsomal assays, respectively. In HepG2 cells, NB-598 inhibits cholesterol synthesis (IC50 = 3.4 nM) without affecting triglycerides, phospholipids, or fatty acids. In vivo, it reduces serum cholesterol in rodents and dogs by upregulating LDL receptor activity. Thus, NB-598 serves as a valuable compound in hypercholesterolemia and atherosclerosis research.
| Storage | Store at -20°C |
| M.Wt | 486.13 |
| Cas No. | 136719-25-0 |
| Formula | C27H32ClNOS2 |
| Synonyms | NB 598 hydrochloride;NB598 hydrochloride |
| Solubility | ≥54 mg/mL in DMSO with gentle warming, ≥49.3 mg/mL in EtOH with gentle warming,insoluble in H2O |
| Chemical Name | (E)-N-ethyl-6,6-dimethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]hept-2-en-4-yn-1-amine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CCN(CC=CC#CC(C)(C)C)CC1=CC(=CC=C1)OCC2=CC(=CS2)C3=CSC=C3.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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