NB-598
NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. SE inhibitor NB-598 significantly inhibited both basal and glucose-stimulated insulin secretion from mouse pancreatic islets. CaV channels were markedly inhibited by NB-598.
| Physical Appearance | A brown oil |
| Storage | Store at -20°C |
| M.Wt | 449.67 |
| Cas No. | 131060-14-5 |
| Formula | C27H31NOS2 |
| Synonyms | NB 598;NB598 |
| Solubility | insoluble in H2O; ≥49.3 mg/mL in EtOH with gentle warming; ≥54 mg/mL in DMSO with gentle warming |
| Chemical Name | (E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine |
| SDF | Download SDF |
| Canonical SMILES | CCN(C/C=C/C#CC(C)(C)C)Cc1cccc(OCc2cc(-c3c[s]cc3)c[s]2)c1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
MIN6 cells, as well as mouse and human pancreatic islets |
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Reaction Conditions |
10 μM NB-598 for 48 h incubation |
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Applications |
Cholesterol reduction of 36 ~ 52% was observed in MIN6 cells, mouse and human pancreatic islets after a 48-h incubation with 10 μM NB-598. A similar reduction in cholesterol was observed in the subcellular compartments of MIN6 cells. In addition, inhibition of cholesterol biosynthesis by NB-598 impaired insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Xia F, Xie L, Mihic A, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology, 2008, 149(10): 5136-5145. |
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Quality Control & MSDS
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Chemical structure
