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Z-Ligustilide

Catalog No.
N1901
facilitates blood circulation and attenuates inflammatory pain behavior
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
100mg
$380.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

IC50: 2.27 and 4.78 μM against L1210 and K562 cell lines

Z-Ligustilide, isolated and purified from the essential oil of A. sinensis. Z-Ligustilide has been reported to facilitate blood circulation and attenuate inflammatory pain behavior.

In vitro: Previous results showed pretreatment with Z-Ligustilide (LIG) improved cell viability significantly. The apoptosis rate in glutamate-induced PC12 cells decreased in the presence of LIG. Western blot results indicated that LIG could decrease the release of Cyt C from mitochondria, up-regulate Bcl-2/Bax ratio and down-regulate Caspase-3 protein expression, resulting in protecting PC12 cells from apoptosis [1].

In vivo: In ovariectomized (OVX) osteopenic rats, the anti-inflammatory potential of LIG was determined by ELISA. LIG was found to be able to inhibit OVX-induced up-regulation of NF-κB activation and the production of TNF-α, iNOS, IL-1β, ICAM-1 and COX-2 significantly. In addition, LIG could suppress MDA and PMN infiltration. The significant anti-inflammatory effect of Z-Ligustilide in experimental OVX osteopenic rats clearly demonstrated that there might be an inflammatory component in the etiology of osteoporosis [2].

Clinical trial: N/A

References:
[1] Wu Q,Wang N,Wang Y,Wang GY,Piao XX.  rotective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao.2015 Feb;50(2):162-8.
[2] Ma Z,Bai L.  The anti-inflammatory effect of Z-Ligustilide in experimental ovariectomized osteopenic rats. Inflammation.2012 Dec;35(6):1793-7.

Chemical Properties

StorageStore at -20°C
M.Wt190.24
Cas No.4431-01-0
FormulaC12H14O2
Solubility≥16.45mg/mL in DMSO
Chemical Name(Z)-3-butylidene-4,5-dihydroisobenzofuran-1(3H)-one
SDFDownload SDF
Canonical SMILESO=C1O/C(C2=C1C=CCC2)=C\CCC
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control