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Windorphen

Catalog No.
B5977
Wnt inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
5mg
$55.00
In stock
25mg
$200.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling for ventral development.

Wnt protein is a family of signaling proteins that interacts on the Wnt/β-Catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.

In canonical Wnt/β-catenin reporter cell line STF293, Windorphen dose-dependently inhibits Wnt3a-inducible TOPFLASH-luciferase activity (IC50 of 1.5 mM). In human colon adenocarcinoma

SW480 cells with defective APC gene that constitutively activates Wnt signaling, 72 h treatment of Windorphen causes a wide spread apoptosis. [1]

In zebrafish embryos, Windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). Windorphen selectively inhibits Wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). In addition, Windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective Axin1/β-catenin destruction complex causes abnormal activation of Wnt signaling and the loss of telencephalon and eyes.) [1]

Reference:
1.  Hao J, Ao A, Zhou L et al. Selective small molecule targeting β-catenin function discovered by in
vivo chemical genetic screen.  Cell Rep. 2013 Sep 12;4(5):898-904.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt302.75
Cas No.19881-70-0
FormulaC17H15ClO3
Solubilityinsoluble in EtOH; insoluble in H2O; ≥11.45 mg/mL in DMSO
Chemical Name(E)-3-chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
SDFDownload SDF
Canonical SMILESO=C/C(C1=CC=C(OC)C=C1)=C(Cl)\C2=CC=C(OC)C=C2
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Windorphen