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SB269970 HCl

Catalog No.
B2254
5-HT7 receptor antagonist,potent and selective
Grouped product items
SizePriceStock Qty
10mg
$212.00
In stock
50mg
$704.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

SB269970 HCl is a potent and selective antagonist of 5-HT7 receptor with pKi value of 8.3 [1].

SB269970 is a selective antagonist of 5-HT7 receptor. It shows at least 100-fold selective against 5-HT7 over a variety of receptors and enzymes. SB269970 prevents 5-CT from binding to h5-HT7(a) in H293 cells and human cloned 5-HT7 receptor in guinea-pig cerebral cortex membranes with pKi values of 8.9 and 8.3, respectively. SB269970 also inhibits adenylyl cyclase activity stimulated by 5-CT both in 5-HT7(a)/ HEK293 (pA2 of 8.5) membranes and in guinea-pig hippocampus (pKB of 8.3). In vehicle-treated animals, SB269970 almost completely inhibits the 5-CT-induced hypothermia with ED50 value of 2.96mg/kg [1].

References:
[1] Hagan J J, Price G W, Jeffrey P, et al. Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist. British journal of pharmacology, 2000, 130(3): 539-548.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt388.95
Cas No.261901-57-9
FormulaC18H29ClN2O3S
SolubilitySoluble in DMSO
Chemical Name3-[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonylphenol;hydrochloride
SDFDownload SDF
Canonical SMILESCC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Biological Activity

Description SB269970 HCl is an antagonist of 5-HT7 receptor with a pKi value of 8.3.
Targets 5-HT7          
IC50 8.3(pKi)          

Quality Control

Quality Control & MSDS

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Chemical structure

SB269970 HCl