SB269970 HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SB269970 HCl is a potent and selective antagonist of 5-HT7 receptor with pKi value of 8.3 [1].
SB269970 is a selective antagonist of 5-HT7 receptor. It shows at least 100-fold selective against 5-HT7 over a variety of receptors and enzymes. SB269970 prevents 5-CT from binding to h5-HT7(a) in H293 cells and human cloned 5-HT7 receptor in guinea-pig cerebral cortex membranes with pKi values of 8.9 and 8.3, respectively. SB269970 also inhibits adenylyl cyclase activity stimulated by 5-CT both in 5-HT7(a)/ HEK293 (pA2 of 8.5) membranes and in guinea-pig hippocampus (pKB of 8.3). In vehicle-treated animals, SB269970 almost completely inhibits the 5-CT-induced hypothermia with ED50 value of 2.96mg/kg [1].
References:
[1] Hagan J J, Price G W, Jeffrey P, et al. Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist. British journal of pharmacology, 2000, 130(3): 539-548.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 388.95 |
| Cas No. | 261901-57-9 |
| Formula | C18H29ClN2O3S |
| Solubility | Soluble in DMSO |
| Chemical Name | 3-[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonylphenol;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl |
| Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
| Description | SB269970 HCl is an antagonist of 5-HT7 receptor with a pKi value of 8.3. | |||||
| Targets | 5-HT7 | |||||
| IC50 | 8.3(pKi) | |||||
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
