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Serine Protease

Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.

Compare Products

  1. Cat.No. Product Name Information
  2. A2574 Aprotinin

    Aprotinin, a naturally occurring serine protease inhibitor, saves lives and decreases the risk of stroke and repeat surgery for massive bleeding.

  3. C5589 Chymostatin
  4. C5839 Tosyllysine Chloromethyl Ketone (hydrochloride)
  5. C4437 UCF 101
  6. C3393 PPACKII (trifluoroacetate salt)
  7. A2586 Nafamostat Mesylate(FUT-175) Nafamostat mesylate, previously known as FUT-175, is an inhibitor of serine protease that inhibits a variety of serine proteases, including trypsin and several proteases in the coagulation cascade.
  8. A2573 AEBSF.HCl

    AEBSF is a broad spectrum, irreversible inhibitor of serine proteases .

  9. A2570 Leupeptin, Microbial Leupeptin is a reversible inhibitor of protease with Ki values of 35 nM, 3.4 μM, 6 nM and 72 nM for bovine trypsin, human plasmin, bovine spleen cathepsin B and recombinant human calpain, respectively.
  10. A2587 PMSF

    PMSF (Phenylmethanesulfonyl fluoride) is an irreversible inhibitor of serine proteinases, which is associated with the development of the delayed organophosphorus neuropathy.

  11. A3234 BCX 1470 IC50: FD 96 nM, C1 1.6 nM

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