Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.
- Cat.No. Product Name Information
Aprotinin, a naturally occurring serine protease inhibitor, saves lives and decreases the risk of stroke and repeat surgery for massive bleeding.
- C5589 Chymostatin
- C5839 Tosyllysine Chloromethyl Ketone (hydrochloride)
- C4437 UCF 101
- C3393 PPACKII (trifluoroacetate salt)
- A2586 Nafamostat Mesylate(FUT-175) Nafamostat mesylate, previously known as FUT-175, is an inhibitor of serine protease that inhibits a variety of serine proteases, including trypsin and several proteases in the coagulation cascade.
AEBSF is a broad spectrum, irreversible inhibitor of serine proteases .
- A2570 Leupeptin, Microbial Leupeptin is a reversible inhibitor of protease with Ki values of 35 nM, 3.4 μM, 6 nM and 72 nM for bovine trypsin, human plasmin, bovine spleen cathepsin B and recombinant human calpain, respectively.
PMSF (Phenylmethanesulfonyl fluoride) is an irreversible inhibitor of serine proteinases, which is associated with the development of the delayed organophosphorus neuropathy.
- A3234 BCX 1470 IC50: FD 96 nM, C1 1.6 nM
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