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MMP

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

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  1. Cat.No. Product Name Information
  2. A1038 Amyloid β-Peptide (10-20) (human) Initiates neurodegeneration in Alzheimer disease
  3. A4432 ARP 100 Selective MMP-2 inhibitor
  4. A4433 ARP 101 MMP inhibitor,potent and selective
  5. A2577 Batimastat (BB-94) MMP inhibitor
  6. C4501 cis-ACCP type IV collagen-specific MMP-2 and MMP-9 inhibitor
  7. A4434 CL 82198 hydrochloride Selective MMP-13 inhibitor
  8. A4435 CP 471474 Broad spectrum MMP inhibitor
  9. A3334 CTS-1027 MMPs inhibitor
  10. B5981 DC_AC50 Selective Atox1 and CCS inhibitor
  11. A8420 Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent

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