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Microtubule/Tubulin

Biochemicals

  1. Cat.No. Product Name Information
  2. A3128 7-xylosyltaxol taxol (Paclitaxel) derivative
  3. A1623 Epothilone A macrolide antitumor agent
  4. B4757 INH6 INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
  5. B2298 Plinabulin (NPI-2358) vascular disrupting agent (VDA) and tubulin-depolymerizing inhibitor
  6. B2157 Cabazitaxel Cabazitaxel(XRP6258; RPR-116258A) is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
  7. B1320 Cys-mcMMAD Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
  8. B1634 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Combretastatin A-4 phosphate (fosbretabulin) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.
  9. B3386 Eribulin mesylate Eribulin Mesylate (E7389 Mesylate), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules.
  10. B3387 Eribulin Eribulin (E7389; ER-086526), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules.
  11. A1630 Epothilone B (EPO906, Patupilone) macrolide antitumor agent
  12. A3910 Vc-MMAD antibody drug conjugate.
  13. A3731 Podophyllotoxin Podophyllotoxin
  14. A3370 Docetaxel Trihydrate Docetaxel Trihydrate
  15. A3344 D-64131 D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin. D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM).
  16. A3394 Epothilone D natural polyketide compound isolated from the myxobacterium Sorangium cellulosum.
  17. A3324 Colchicine Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM).
  18. A3590 Mc-MMAD Potent tubulin inhibitor
  19. A3630 MMAD Potent tubulin inhibitor
  20. A3631 Monomethyl auristatin E Antimitotic agent
  21. B3680 Griseofulvin
  22. B1636 Vinflunine Tartrate Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. Phase 2/3.
  23. B1635 CYT997 (Lexibulin) CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 1/2.
  24. B3062 CW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.
  25. B1035 Dolastatin 10 Dolastatin 10 is an antitumor agent .
  26. B3058 CK-636 CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
  27. B3526 Vintafolide
  28. B1136 Nemorubicin anticancer drug