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Palifosfamide

Catalog No.
A3696
Active metabolite of ifosfamide (IFOS)
Grouped product items
SizePriceStock Qty
5mg
$232.00
In stock
10mg
$335.00
In stock
50mg
$902.00
In stock
200mg
$2,520.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Palifosfamide is the active moiety of ifosfamide (IFA) [1].
IFA is alkylating agents which are active against a variety of pediatric sarcomas such as rhabdomyosarcoma (RMS), Ewing’s sarcoma (ES), osteosarcoma (OS) and other undifferentiated soft tissue sarcomas [1].
In human OS cell lines SaOS-2, OS229 and OS230, Palifosfamide lysine has broad activity with IC50 ranging from 2.25 to 6.75 μM. While OS222 had the IC50 of 31.5 μM [1].
In CB17 female SCID mice, palifosfamide lysine (100 mg/kg) administered intravenously for three consecutive days, the mean weight loss was less than 15% and complete recovery to baseline within 4 weeks of treatment. While, doses higher than 100 mg/kg for three consecutive days lead to either greater than 20% loss of body weight or death. In NCr-nu/nu mice bearing established orthotopic mammary MX-1 tumor xenografts, palifosfamide suppressed MX-1 tumor growth by greater than 80% with 17% complete antitumor responses [2].
References:
[1]. Hingorani P, Zhang W, Piperdi S, et al. Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol, 2009, 64(4): 733-740.
[2]. Jones B, Komarnitsky P, Miller GT, et al. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs, 2012, 23(2): 173-184.

Chemical Properties

StorageStore at -20°C
M.Wt221.02
Cas No.31645-39-3
FormulaC4H11Cl2N2O2P
SynonymsIsophosphoramide mustard;IPM;ZIO-201
Solubility≥22.1 mg/mL in DMSO; insoluble in EtOH; ≥19.4 mg/mL in H2O with gentle warming and ultrasonic
Chemical Namebis(2-chloroethylamino)phosphinic acid
SDFDownload SDF
Canonical SMILESC(CCl)NP(=O)(NCCCl)O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control