ML385
Catalog No.
B8300
NRF2 inhibitor
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ML385 (CAS 846557-71-9) is a selective inhibitor of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), displaying an IC50 of 1.9 μM. NRF2 regulates cellular antioxidant responses, detoxification pathways, and multidrug transporters, and its activation is frequently implicated in therapeutic resistance of non-small cell lung cancer (NSCLC). In A549 cells, ML385 treatment reduces expression of NRF2-dependent genes dose- and time-dependently. Additionally, in NSCLC mouse models, ML385 treatment diminished tumor growth and metastasis, especially when combined with carboplatin, underscoring its utility in cancer research and potential therapeutic exploration.
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| Storage | Store at -20°C |
| M.Wt | 511.59 |
| Cas No. | 846557-71-9 |
| Formula | C29H25N3O4S |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥13.33 mg/mL in DMSO |
| Chemical Name | 2-(benzo[d][1,3]dioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)indolin-5-yl)thiazol-2-yl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(CC1=CC2=C(C=C1)OCO2)NC3=NC(C4=CC=C5N(CCC5=C4)C(C6=C(C=CC=C6)C)=O)=C(S3)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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