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Imatinib Mesylate (STI571)

Multi-target kinase inhibitor of abl, c-kit, and PDGFR

Imatinib Mesylate (STI571)

Catalog No. A1805
Size Price Stock Qty
Evaluation Sample $28.00  All Inclusive In stock
100mg $100.00 In stock

All inclusive: Shipping and all other fees included

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Imatinib Mesylate (STI571)

Related Biological Data

Imatinib Mesylate (STI571)

Related Biological Data

Imatinib Mesylate (STI571)

Biological Activity

Description Imatinib Mesylate (STI571), an orally bioavailability mesylate salt of Imatinib, is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
Targets v-Abl PDGFR c-Kit      
IC50 600 nM 100 nM 100 nM      

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Chemical Properties

Cas No. 220127-57-1 SDF Download SDF
Chemical Name methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Canonical SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
Formula C29H31N7O.CH4SO3 M.Wt 589.71
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Research Update

2. Effects of imatinib mesylate on the spontaneous activity generated by the guinea-pig prostate. BJU Int. 2013 Aug;112(4):E398-405. doi: 10.1111/j.1464-410X.2012.11660.x.
Abstract
Although inconsistent results have been obtained from studies examining functional role of tyrosine kinase receptors in the generation of spontaneous activity in various segments of the gastrointestinal and urogenital tracts through imatinib mesylate, effects of imatinib mesylate on the spontaneous activity in the young and ageing prostate gland have been reported in detail.
4. Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. Lancet Oncol. 2012 Dec;13(12):1218-24. doi: 10.1016/S1470-2045(12)70414-X. Epub 2012 Oct 23.
Abstract
Imatinib mesylate has been evaluated for its efficacy to decrease the volume burden of plexiforn neurofibromas in NF1 patients.
5. Ageing is a risk factor in imatinib mesylate cardiotoxicity. Eur J Heart Fail. 2014 Feb 6. doi: 10.1002/ejhf.58. [Epub ahead of print]
Abstract
Imatinib mesylate, a tyrosine kinase inhibitor with anticancer activity, causes cardiotoxicity in patients.

Background

Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia c