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E-64-c

inhibits cathepsin B, H, and L

E-64-c

Catalog No. A8162
Size Price Stock Qty
1mg $50.00 In stock
5mg $150.00 In stock
25mg $500.00 In stock
100mg $800.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

E-64-c

Biological Activity

E-64-c is an effective synthetic calpain inhibitor composed from E-64, which also inhibits cathepsin B, cathepsin H, and cathepsin L (cysteine proteases).
Targets cathepsins B cathepsins H cathepsins L      
IC50            

E-64-c Dilution Calculator

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Chemical Properties

Cas No. 76684-89-4 SDF Download SDF
Chemical Name (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
Canonical SMILES CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1C(O1)C(=O)O
Formula C15H26N2O5 M.Wt 314.4
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

E-64-c is an effective synthetic calpain inhibitor composed from E-64, which also inhibits cathepsin B, cathepsin H, and cathepsin L (cysteine proteases). The compound has been demonstrated to form a complex with papain by binding via a thioether covalent bond. Studies indicate that E-64-c, also known as Ep-475, is a more potent inhibitor of cathepsins B and L compared to E-64. Mouse lymphosarcoma LS studies show that Ep-475 decreases the effects of cyclophosphamide.