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Cyproheptadine hydrochloride

Catalog No.
serotonin and histamine antagonist as well as antimuscarinic reagent
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
In stock
Evaluation Sample
In stock
In stock

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Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1].

Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent. It is used to treat for postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing's syndrome. The major urinary product of cyproheptadine is cyproheptadine glucuronide, a quaternary ammonium compound. Cyproheptadine has some side effects including sedation, drowsiness, hypotension, tachycardia and blood dyscrasias. As a 5-HT2A receptor antagonist, cyproheptadine is found to reverse serotonin-enhanced ADP-induced platelet aggregation in vitro and ex vivo suggesting its antiplatelet and thromboprotective effects. [1, 2]

[1] Levine B, Green-Johnson D, Hogan S, Smialek JE.  A cyproheptadine fatality. J Anal Toxicol. 1998 Jan-Feb;22(1):72-4.
[2] Lin OA, Karim ZA, Vemana HP, Espinosa EV, Khasawneh FT.  The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at -20°C
Cas No.969-33-5
Solubility≥14.15mg/mL in DMSO
Chemical Name4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine;hydrochloride
SDFDownload SDF
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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