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Corticosterone

Catalog No.
B7469
Endogenous glucocorticoid
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
50mg
$53.00
In stock

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Email: [email protected]

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Background

Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors[1]. 

Corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane. It provides a potential mechanism underlying the role of corticosteroid stress hormone in up-regulating excitatory synaptic efficacy in cortical neurons[2]. 

References:

[1]. Lu NZ, Wardell SE, Burnstein KL, et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: Glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol, 2006, 58(4): 782-797.

[2]. Liu W, Yuen E Y, Yan Z. The Stress Hormone Corticosterone Increases Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex. Journal of Biological Chemistry, 2010, 285(9): 6101-6108.

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt346.46
Cas No.50-22-6
FormulaC21H30O4
Solubility≥14.5mg/mL in DMSO
Chemical Name(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
SDFDownload SDF
Canonical SMILESO[[email protected]@H]1[[email protected]]([[email protected]](CC2)(C)C3=CC2=O)[[email protected]@H](CC3)[[email protected]]4[[email protected]]([[email protected]@H](C(CO)=O)CC4)(C)C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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