Toggle Nav
Close
  • Menu
  • Setting

Corticosterone

Catalog No.
B7469
Endogenous glucocorticoid
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
50mg
$53.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Corticosterone (CAS 50-22-6) is an endogenous steroid hormone secreted by the adrenal cortex, which exhibits affinity toward both glucocorticoid and mineralocorticoid receptors. Its mechanism of action involves serum- and glucocorticoid-inducible kinase (SGK)-mediated phosphorylation of GDP dissociation inhibitor (GDI) at Ser-213, thereby promoting GDI-Rab4 complex assembly. This activity enhances Rab4-dependent recycling of AMPA receptors to cortical neuron synapses, leading to elevated synaptic excitatory responses. Corticosterone thus serves as a useful biochemical tool for investigating stress-related modulation of synaptic transmission and plasticity.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt346.46
Cas No.50-22-6
FormulaC21H30O4
Solubilityinsoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO
Chemical Name(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
SDFDownload SDF
Canonical SMILESO[C@@H]1[C@H]([C@](CC2)(C)C3=CC2=O)[C@@H](CC3)[C@H]4[C@]([C@@H](C(CO)=O)CC4)(C)C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control