Corticosterone
Catalog No.
B7469
Endogenous glucocorticoid
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Corticosterone (CAS 50-22-6) is an endogenous steroid hormone secreted by the adrenal cortex, which exhibits affinity toward both glucocorticoid and mineralocorticoid receptors. Its mechanism of action involves serum- and glucocorticoid-inducible kinase (SGK)-mediated phosphorylation of GDP dissociation inhibitor (GDI) at Ser-213, thereby promoting GDI-Rab4 complex assembly. This activity enhances Rab4-dependent recycling of AMPA receptors to cortical neuron synapses, leading to elevated synaptic excitatory responses. Corticosterone thus serves as a useful biochemical tool for investigating stress-related modulation of synaptic transmission and plasticity.
- 1. Yaling Fu, Xiangfei Guo, et al. "Hippocampal BAIAP2 prevents chronic mild stress-induced depression-like behaviors in mice." Front Psychiatry. 2023 May 10:14:1192379. PMID: 37234209
- 2. Xiaorui Shi, Yuan Gao, et al. "Sulfur dioxide derivatives produce antidepressant- and anxiolytic-like effects in mice." Neuropharmacology. 2020 Oct 1;176:108252. PMID:32712276
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 346.46 |
| Cas No. | 50-22-6 |
| Formula | C21H30O4 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO |
| Chemical Name | (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1[C@H]([C@](CC2)(C)C3=CC2=O)[C@@H](CC3)[C@H]4[C@]([C@@H](C(CO)=O)CC4)(C)C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
