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Methylprednisolone

Catalog No.
A4233
Apoptosis inducer,GR agonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$80.00
In stock
100mg
$75.00
In stock
250mg
$100.00
In stock
500mg
$150.00
In stock
1g
$200.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

Methylprednisolone (CAS 83-43-2) is a synthetic glucocorticoid receptor agonist that exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines, notably TNF-α, and modulating NF-κB signaling pathways. In vitro studies demonstrate that methylprednisolone reduces TNF production and enhances IL-10 synthesis in mouse macrophages upon LPS stimulation, suppresses chemokine secretion from human peripheral blood mononuclear cells, and inhibits acantholysis in skin cultures. Animal models indicate that intravenous methylprednisolone administration attenuates inflammation, decreases macrophage infiltration and tissue damage post-spinal cord injury. Clinically, methylprednisolone is investigated for therapeutic use in acute spinal cord injury, severe vasculitis, and lupus nephritis.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt374.48
Cas No.83-43-2
FormulaC22H30O5
Solubilityinsoluble in H2O; ≥15.35 mg/mL in DMSO; ≥9.5 mg/mL in EtOH with ultrasonic
Chemical Name(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
SDFDownload SDF
Canonical SMILESCC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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