Methylprednisolone
Methylprednisolone (CAS 83-43-2) is a synthetic glucocorticoid receptor agonist that exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines, notably TNF-α, and modulating NF-κB signaling pathways. In vitro studies demonstrate that methylprednisolone reduces TNF production and enhances IL-10 synthesis in mouse macrophages upon LPS stimulation, suppresses chemokine secretion from human peripheral blood mononuclear cells, and inhibits acantholysis in skin cultures. Animal models indicate that intravenous methylprednisolone administration attenuates inflammation, decreases macrophage infiltration and tissue damage post-spinal cord injury. Clinically, methylprednisolone is investigated for therapeutic use in acute spinal cord injury, severe vasculitis, and lupus nephritis.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 374.48 |
| Cas No. | 83-43-2 |
| Formula | C22H30O5 |
| Solubility | insoluble in H2O; ≥15.35 mg/mL in DMSO; ≥9.5 mg/mL in EtOH with ultrasonic |
| Chemical Name | (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| SDF | Download SDF |
| Canonical SMILES | CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
