12-oxo Phytodienoic Acid

12-oxo Phytodienoic Acid (CAS No.: 85551-10-6) is a bioactive plant lipid-derived oxylipin that functions as an endogenous signaling molecule and a key intermediate in the biosynthesis of jasmonates, while also exerting distinct biological activities independent of jasmonic acid pathways. It is widely recognized for its anti-inflammatory and immunomodulatory properties, particularly through the inhibition of lipopolysaccharide-induced signaling cascades, including suppression of NF-κB and p38 MAPK activation, thereby attenuating pro-inflammatory responses and neuroinflammation in cellular systems. Beyond its role in plant defense and stress signaling, this compound has been shown to regulate programmed cell death and enhance secondary metabolite production, such as alkaloid biosynthesis in plant-derived cell cultures, highlighting its broader function as a signal transducer. In vitro studies typically demonstrate activity in the low micromolar range, depending on the cellular context and assay design. Owing to its capacity to modulate conserved inflammatory and stress-related pathways, 12-oxo Phytodienoic Acid is increasingly utilized in biomedical research, particularly in studies of neurodegenerative diseases, inflammation-driven pathologies, and signal transduction mechanisms, as well as in screening platforms aimed at identifying modulators of innate immune and stress response pathways, with experimental concentrations tailored to specific model systems and research objectives.