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Artemether (SM-224)

Catalog No.
Semi-synthetic derivative of artemisinin
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
In stock
In stock

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Artemether is a semi-synthetic derivative of artemisinin (qinghaosu), a naturally occurring peroxide lactone derived from a traditional Chinese herbal remedy Artemisia annua L., to enhance the solubility and antimalarial activity of its parental compound. Artemether exhibits potent antimalarial and antischistosomal activities against malarial parasites and Schistosoma japonicum infections. Although it has not been well elucidated, an endoperoxide bridge within the chemical structure of Artemether might be the key characteristic considered to be responsible for its antimalarial and antischistosomal activities, which can be metabolized by malarial or schistosomal parasites, under in vivo conditions, generating detrimental oxygen radicals to attack parasite macromolecules.


Xiao Shuhua and Brian A. Catto.  In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 1989, 1557-1562

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.71963-77-4
Solubility≥15.3 mg/mL in DMSO, ≥90.2 mg/mL in EtOH,insoluble in H2O
Chemical Name(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
SDFDownload SDF
Canonical SMILES[H][[email protected]]12[[email protected]@]3([[email protected]@]4([H])CC[[email protected]@]2([H])C)[[email protected]@](O[[email protected]](OC)[[email protected]@]4(C)[H])([H])O[[email protected]@](OO3)(C)CC1
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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