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APExBIO

4'-Demethylepipodophyllotoxin

In stock
Catalog No.
A3123
Anti-cancer drug
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
500mg
$130.00
In stock
1g
$187.00
In stock

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Description: IC50 Value: 0.31uM(EC50 for HL60 cell, MTT assay, 48h); 0.37uM(EC50 for HepG2 cell, MTT assay, 48h) [1] 4'-demethylepipodophyllotoxin is a key intermediate compounds for the preparation of podophyllotoxin-type anti-cancer drugs. in vitro: 4-TMP-DMEP showed strong cytotoxicity activity against the above-mentioned five tumor cell lines. The EC50s of 4-TMP-DMEP against these tumor cell lines ranged from 0.24 to 0.11 μM, which were 0.29 to 3618 times lower than that of DMEP [1]. in vivo: Treatment of animals with DMEP (until the end of the experiment), 30 min before TPA treatment, significantly reduced the tumor incidence, tumor volume and the conversion efficiency of papillomas to squamous cell carcinomas. The tumor formation and growth was also delayed by DMEP pre-treatment [2]. Clinical trial: N/A

Physical Appearance

A solid

Chemical Properties

StorageStore at -20°C
M.Wt400.38
Cas No.6559-91-7
FormulaC21H20O8
Synonyms4'-O-demethylepipodophyllotoxin;4'-DMEP
Solubility≥83.3 mg/mL in DMSO, <2.72 mg/mL in EtOH, <2.58 mg/mL in H2O
Chemical Name6-oxo-1H-pyrazine-3-carboxylic acid
SDFDownload SDF
Canonical SMILESCOC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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