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360A G-quadruplex structures inhibitor

Catalog No.A3119
Size Price Stock
5mg
$233.00
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10mg
$355.00
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25mg
$514.00
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50mg
$841.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

360A

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Chemical Properties

Cas No. 794458-56-3 SDF Download SDF
Synonyms 360 A
Chemical Name 3,3'-((pyridine-2,6-dicarbonyl)bis(azanediyl))bis(1-methylquinolin-1-ium)
Canonical SMILES CN1=C2C=CC=CC2=C/C(C=1)=[NH+]/C(C3=NC(C(/[NH+]=C4C=C5C=CC=CC5=N(C)=C/4)=O)=CC=C3)=O
Formula C27H23N5O2 2+ M.Wt 449.5
Solubility 25℃: DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Description: IC50 Value: N/A 360A is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for G-quadruplex structures and selective telomerase inhibition in vitro assays. 360A is a G-quadruplex ligand, which can influence the consequence of G-quadruplex formation and/or stabilization. in vitro: We found a S-phase accumulation in ATM-proficient, but not in ATM-deficient EBV-lymphocytes treated with 360A before induction of cell death. However, ATM status did not modify cell cycle distribution in 360A-treated SV40-fibroblasts and HeLa cells compared to DMSO treated controls [1]. DNA-PKcs-dependent NHEJ was responsible for sister telomere fusions as a direct consequence of G-quadruplex formation and/or stabilization induced by 360A on parental telomere G strands. NHEJ and HR activation at telomeres altered mitotic progression in treated cells [2]. This compound was shown to display a potent affinity and selectivity for telomeric G-quadruplex DNA over duplex DNA and to induce delayed growth inhibition in HT1080 tumor cell line [3]. in vivo: N/A Clinical trial: N/A