Toggle Nav
Close
  • Menu
  • Setting

TTP 22

Catalog No.
A3894
CK2 inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$121.00
In stock
10mg
$102.00
In stock
50mg
$462.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

IC50= 0.1 μM; Ki= 40 nM

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor.

Casein kinase 2 (CK2) noticeably stands out against a background of the kinase family due to its constitutive catalytic activity with the ability to phosphorylate more than 300 physiological substrates. These features make CK2 appear greatly diverse points of cell signaling pathways and be involved in processes leading to the development of various disorders, especially cancer. Thus, currently CK2 is regarded as druggable protein kinase target and can be used for the development of antitumor, anti-inflammatory and antiviral drugs.

In vitro: Kinetic studies of TTP 22 showed that activity of (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids moiety was a result of its competition with ATP molecule for the binding site. Inhibition constant (Ki) for TTP 22 was 40 nM. Initial in vitro tests of TTP 22 and it analog on four serine/threonine (ASK1, JNK3, Aurora A and Rock 1) and three tyrosine protein kinases (FGFR1, Met and Tie2) revealed their remarkable specificity towards CK2 [1].

In vivo: So far, no animal in vivo study has been conducted for TTP 22.

Clinical trial: N/A

Reference:
[1] Golub AG,Bdzhola VG,Briukhovetska NV,Balanda AO,Kukharenko OP,Kotey IM,Ostrynska OV,Yarmoluk SM.  Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem.2011 Mar;46(3):870-6.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt330.42
Cas No.329907-28-0
FormulaC16H14N2O2S2
SynonymsTTP22;TTP-22
Solubilityinsoluble in H2O; ≥16.5 mg/mL in DMSO; ≥7.85 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid
SDFDownload SDF
Canonical SMILESCC1=CC=C(C=C1)C2=CSC3=C2C(=NC=N3)SCCC(=O)O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

TTP 22

Related Biological Data

TTP 22