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TBB

Catalog No.
A3861
Casein kinase-2 (CK2) inhibitor
Grouped product items
SizePriceStock Qty
10mg
$56.00
In stock
50mg
$172.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt434.71
Cas No.17374-26-4
FormulaC6HBr4N3
SynonymsNSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole, 4,5,6,7-tetrabromo-
Solubilityinsoluble in H2O; ≥159.2 mg/mL in DMSO; ≥10.42 mg/mL in EtOH with ultrasonic
Chemical Name4,5,6,7-tetrabromo-2H-benzotriazole
SDFDownload SDF
Canonical SMILESC1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

TBB

Related Biological Data

TBB

Related Biological Data

TBB