Protein Ser/Thr Phosphatases
Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
- C3607 PTP Inhibitor ISummary: tyrosine phosphatase (PTP) inhibitor
- C3898 Cantharidic Acid (sodium salt)Summary: PP1 and PP2A inhibitor
- C3996 PRL-3 InhibitorSummary: phosphatase of regenerating liver 3 (PRL-3) inhibitor
- C4347 β-Glycerophosphate (sodium salt hydrate)Summary: protein phosphatase inhibitor
- C4401 PTP Inhibitor IVSummary: PTP inhibitor
- C4614 bpV(HOpic) (potassium salt, technical grade)Summary: protein tyrosine phosphatases (PTPs) inhibitor
- B1177 NafamostatSummary: Broad spectrum serine protease inhibitor, kallikrein inhibitor
- B1178 Nafamostat hydrochlorideSummary: Synthetic serine protease inhibitor
- B6881 NSC 6632841 CitationSummary: Cdc25 dual specificity phosphatases inhibitor
- B7009 TautomycetinSummary: A novel and specific protein phosphatase 1 (PP1) inhibitor